Full Prescribing Information Important Safety Information
History of Prograf
Why Prograf?
Long-term Health?
Transplant Experience
Transplant Experience
 My life is my evidence
Patients & Caregivers

History of Prograf

Prograf® (tacrolimus) was discovered in 1984 by Fujisawa scientists in Tsukuba, Japan. Its discovery helped transform the success of transplantation, making it an option that more people could benefit from.

Prograf was approved for the prevention of organ rejection in liver transplant recipients in 1994, in kidney transplant recipients in 1997, and in heart transplant recipients in 2006. Over the years, it has helped many people enjoy greater transplant success—many of whom continue to share their stories today.

Visit www.TransplantExperience.com and read inspirational stories from other transplant recipients on the ways they’ve benefited from Prograf. And be sure to register with Transplant Experience to receive information, advice and support for the years ahead.
The information provided on this website is intended for residents of the United States
Important Safety Information
  • Only physicians and facilities specializing in transplantation should manage patients taking Prograf. Anti-rejection medications may result in an increased possibility of developing an infection or lymphoma, a type of cancer.
  • In clinical studies, up to 20% of patients taking Prograf developed insulin-dependent diabetes after transplant, but in some patients, after one to two years, insulin was no longer required. Black and Hispanic kidney transplant patients were at an increased risk.
  • Prograf has been associated with toxicity to the kidneys and nervous system. Common side effects are tremor, headache, high blood pressure, diarrhea, nausea, constipation, stomach pain, changes in kidney function, high blood sugar, low white cell count, infection, and high cholesterol/lipid levels.
  • Some people should not take Prograf. If you are allergic to Prograf or any of its components, you should not take Prograf.
  • Be sure to tell your doctor right away if you notice that you are thirstier than usual, have to urinate more often, have blurred vision, or seem to get confused. These may be the early signs of high blood sugar or diabetes. Additionally, tell your doctor if you are pregnant, planning to have a baby, or breastfeeding.
  • You will need to take Prograf exactly the way your doctor tells you to. Make sure you take it before or after you eat at the same times each day. Do not eat grapefruit or drink grapefruit juice in combination with Prograf.
  • Some medicines, such as certain antibiotics, will affect your body’s ability to use Prograf. Always make sure your doctor knows you are taking Prograf when you receive a new medicine, including any over-the-counter medicines or herbal supplements.
  • Medication regimens will vary between transplant recipients. Talk to your transplant team to find the combination of medicines that is right for you.