Important Safety Information

• Only physicians and facilities specializing in transplantation should manage patients taking Prograf. Anti-rejection medications may result in an increased possibility of developing an infection or lymphoma, a type of cancer.
• In clinical studies, up to 20% of patients taking Prograf developed insulin-dependent diabetes after transplant, but in some patients, after one to two years, insulin was no longer required. Black and Hispanic kidney transplant patients were at an increased risk.
• Prograf has been associated with toxicity to the kidneys and nervous system. Common side effects are tremor, headache, high blood pressure, diarrhea, nausea, constipation, stomach pain, changes in kidney function, high blood sugar, low white cell count, infection, and high cholesterol/lipid levels.
• Some people should not take Prograf. If you are allergic to Prograf or any of its components, you should not take Prograf.
• Be sure to tell your doctor right away if you notice that you are thirstier than usual, have to urinate more often, have blurred vision, or seem to get confused. These may be the early signs of high blood sugar or diabetes. Additionally, tell your doctor if you are pregnant, planning to have a baby, or breastfeeding.
• You will need to take Prograf exactly the way your doctor tells you to. Make sure you take it before or after you eat at the same times each day. Do not eat grapefruit or drink grapefruit juice in combination with Prograf.
• Some medicines, such as certain antibiotics, will affect your body’s ability to use Prograf. Always make sure your doctor knows you are taking Prograf when you receive a new medicine, including any over-the-counter medicines or herbal supplements.
• Medication regimens will vary between transplant recipients. Talk to your transplant team to find the combination of medicines that is right for you.