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How eligible patients can save on PROGRAF®(tacrolimus)

Eligible patients may pay as little as $0 with the PROGRAF Copay Carda

PROGRAF Copay Card

Astellas Cares™ about helping patients access the medications you prescribe. That's why we created the PROGRAF Copay Card.

With it, eligible patients with commercial prescription insurance may pay as little as $0 per prescription, for savings up to $3000.a

aEligible participants in the PROGRAF Copay Card Program ("Program") may receive annual savings up to $3000 for PROGRAF. Patients must have prescription drug coverage for PROGRAF. However, this Program offer is not valid for patients whose prescription claims are reimbursed, in whole or in part, by any federal or state-government funded prescription drug benefit program including but not limited to, Medicaid, Medicare, Medigap, Veterans Affairs (VA), Department of Defense (DoD), TRICARE, Puerto Rico Government Insurance, or any state patient or pharmaceutical assistance program. Patients who reside in the states of Massachusetts and California are not eligible to participate in the Program. Furthermore, this offer is not valid in the state of California. The PROGRAF Copay Card Program is valid for twelve (12) months from date of enrollment. Annual reenrollment in the Program is required and subject to eligibility. Restrictions may apply. This offer is void where prohibited by law. Astellas reserves the right to rescind, revoke, or amend this offer without notice.

Receiving the PROGRAF copay card

Patients have multiple ways to receive the card:

  1. Your healthcare provider can provide one to you that you activate online.
  2. Enroll online at the Astellas Copay Program activation page.
    • Eligible patients will be able to download and print a temporary card that can be activated immediately from the website
    • Subsequently, a copay card will be sent to the patient in the mail
  3. Those who receive PROGRAF through the mail can enroll by filling out the "Mail Order" card within the PROGRAF Copay Card brochure or visiting the Patient Rebate Online Portal.

    Enroll Online     Access Mail-Order Rebate Portal

Regardless of how you receive the card, program enrollment is valid for 12 months. Plus, annual reenrollment is required and subject to eligibility. Visit to view eligibility requirements, terms, and conditions.


If you have transplant-related questions, find the answers to many of them at Plus, discover tips and download resources to help manage your health after an organ transplant.

What is PROGRAF?

  • PROGRAF is a prescription medicine used with other medicines to help prevent organ rejection in people who have had a kidney, liver, or heart transplant.
  • PROGRAF capsules and PROGRAF Granules are types of tacrolimus immediate-release drugs and they are not the same as tacrolimus extended-release tablets or tacrolimus extended-release capsules. Your healthcare provider should decide what medicine is right for you.


What is the most important information I should know about PROGRAF?

PROGRAF can cause serious side effects, including:

  1. Increased risk of cancer. People who take PROGRAF have an increased risk of getting some kinds of cancer, including skin and lymph gland cancer (lymphoma).
  2. Increased risk of infection. PROGRAF is a medicine that affects your immune system. PROGRAF can lower the ability of your immune system to fight infections. Serious infections can happen in people receiving PROGRAF that can cause death. Call your healthcare provider right away if you have any symptoms of an infection, including:
  • Fever
  • muscle aches
  • sweats or chills
  • warm, red, or painful areas on your skin
  • cough or flu-like symptoms

Do not take PROGRAF if you are allergic to tacrolimus or any of the ingredients in PROGRAF.

What should I tell my healthcare provider before taking PROGRAF?

Before you take PROGRAF, tell your healthcare provider about all of your medical conditions, including if you:

  • plan to receive any live vaccines (people taking PROGRAF should not receive live vaccines)
  • have or have had liver, kidney or heart problems
  • are pregnant or plan to become pregnant. PROGRAF can harm your unborn baby.
    • If you are able to become pregnant, you should use effective birth control before and during treatment with PROGRAF. Talk to your healthcare provider before starting treatment with PROGRAF about birth control methods that may be right for you.
    • Males who have female partners who are able to become pregnant should also use effective birth control before and during treatment with PROGRAF. Talk to your healthcare provider before starting treatment with PROGRAF about birth control methods that may be right for you.
  • are breastfeeding or plan to breastfeed. PROGRAF passes into your breast milk. You and your healthcare provider should decide if you will breastfeed while taking PROGRAF.

Tell your healthcare provider about all the medicines you take, and when you start a new medicine or stop taking a medicine, including prescription and over-the-counter medicines; vitamins; natural, herbal or nutritional supplements. Especially tell your healthcare provider if you take:

sirolimus (RAPAMUNE®)
cyclosporine (GENGRAF®, NEORAL®, and SANDIMMUNE®)
medicines called aminoglycosides that are used to treat bacterial infections
ganciclovir (CYTOVENE® IV, VALCYTE®)
amphotericin B (ABELCET®, AMBISOME®)
antiviral medicines called nucleoside reverse transcriptase inhibitors
antiviral medicines called protease inhibitors
water pill (diuretic)
medicine to treat high blood pressure
nelfinavir (VIRACEPT®)
telaprevir (INCIVEK®)
letermovir (PREVYMISTM)
itraconazole (ONMEL®, SPORANOX®)
voriconazole (VFEND®)
clarithromycin (BIAXIN®, BIAXIN® XL, PREVPAC®)
rifabutin (MYCOBUTIN®)
amiodarone (NEXTERONE®, PACERONE®)

Ask your healthcare provider or pharmacist if you are not sure if you take any of the medicines listed above. PROGRAF may affect the way other medicines work, and other medicines may affect how PROGRAF works. Know the medicines you take. Keep a list of your medicines and show it to your healthcare provider and pharmacist when you get a new medicine.

How Should I Take PROGRAF?

  • Do not eat grapefruit or drink grapefruit juice while taking PROGRAF.
  • Take PROGRAF exactly as your healthcare provider tells you to take it.
  • Your healthcare provider may change your PROGRAF dose if needed. Do not stop taking or change your dose of PROGRAF without talking to your healthcare provider.
  • Take PROGRAF with or without food, the same way every day. For example, if you choose to take PROGRAF with food, you should always take PROGRAF with food.
  • Take PROGRAF at the same time each day, 12 hours apart. For example, if you take your first dose at 7:00 a.m., you should take your second dose at 7:00 p.m. Taking PROGRAF at the same time each day helps to keep the amount of medicine in your body at a steady level.
  • If you take too much PROGRAF, call your healthcare provider or go to the nearest hospital emergency room right away.

PROGRAF capsules:

  • Do not open or crush PROGRAF capsules.

PROGRAF Granules:

  • Children who have trouble swallowing capsules can be given PROGRAF Granules.
  • Give the dose of PROGRAF Granules right after preparing. Do not save prepared PROGRAF Granules as a liquid to take at a later time.
  • See the Instructions for Use at the end of the Patient Information for detailed instructions about how to mix and give PROGRAF Granules as a liquid.
  • If you get the granules, or prepared oral suspension on your skin, wash the area well with soap and water.
  • If you get the granules, or prepared oral suspension in your eyes, rinse with plain water.

What should I avoid while taking PROGRAF?

  • While you take PROGRAF you should not receive any live vaccines.
  • Limit the amount of time you spend in sunlight and avoid exposure to ultraviolet (UV) light, such as tanning machines. Wear protective clothing and use a sunscreen with a high sun protection factor (SPF).

PROGRAF may cause serious side effects, including:

  • problems from medicine errors. People who take PROGRAF have sometimes been given the wrong type of tacrolimus product. Tacrolimus extended-release medicines are not the same as PROGRAF capsules or granules and cannot be substituted for each other, unless specifically prescribed by your healthcare provider, who will send you to get blood tacrolimus levels at a lab. Check your PROGRAF when you get a new prescription and before you take it to make sure you have received PROGRAF capsules or PROGRAF Granules. Check with the pharmacist and call your healthcare provider if you think you were given the wrong medicine.
  • high blood sugar (diabetes). Your healthcare provider may do blood tests to check for diabetes. Call your healthcare provider right away if you have any symptoms of high blood sugar, including:
    • frequent urination
    • drowsiness
    • increased thirst or hunger
    • loss of appetite
    • blurred vision
    • fruity smell on your breath
    • confusion
    • nausea, vomiting, or stomach pain
  • kidney problems. Kidney problems are a serious and common side effect of PROGRAF. Your healthcare provider may do blood tests to check your kidney function.
  • nervous system problems. Nervous system problems are a serious and common side effect of PROGRAF. Call your healthcare provider right away if you get any of these symptoms that could be signs of a serious nervous system problem:
    • headache
    • changes in behavior
    • confusion
    • coma
    • seizures
    • tremors
    • changes in your vision
    • numbness and tingling
  • high levels of potassium in your blood. Your healthcare provider may do blood tests to check your potassium level.
  • high blood pressure. High blood pressure is a serious and common side effect of PROGRAF. Your healthcare provider will monitor your blood pressure and may prescribe blood pressure medicine for you, if needed. Your healthcare provider may instruct you to check your blood pressure at home.
  • changes in the electrical activity of your heart (QT prolongation).
  • heart problems (myocardial hypertrophy). Tell your healthcare provider right away if you get any of these symptoms of heart problems:
    • shortness of breath
    • feel lightheaded
    • chest pain
    • feel faint
  • severe low red blood cell count (anemia).

The most common side effects of PROGRAF in people who have received a kidney, liver or heart transplant are:

infections in general, including cytomegalovirus (CMV) infection
tremors (shaking of the body)
stomach pain
trouble sleeping
high blood sugar (diabetes)
low levels of magnesium in your blood
low levels of phosphate in your blood
swelling of the hands, legs, ankles, or feet
high levels of fat in your blood
high levels of potassium in your blood
low red blood cell count (anemia)
low white blood cell count
numbness or tingling in your hands and feet
inflammation of your airway (bronchitis)
fluid around your heart

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of PROGRAF. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects.

General information about the safe and effective use of PROGRAF.

  • Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use PROGRAF for a condition for which it was not prescribed. Do not give PROGRAF to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about PROGRAF that is written for health professionals.
  • The Patient Information leaflet summarizes the most important information about PROGRAF. If you would like more information, talk to your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.

Please see the Patient Information and full Prescribing Information, including Boxed Warning.